Lipozene: Is It a Weight-Loss Breakthrough or Simply a Fad?

Written and Medically Reviewed by Babar Shahzad DR, on January 11, 2020.

In the supplement market, science often takes a backseat to marketing gimmicks. Learn the truth about the so-called miracle weight loss pill Lipozene.

Lipozene, sold by Obesity Research Institute, LLC (ORI), is promoted as a super fiber or the weight-loss breakthrough. The ORI website has many positive Lipozene reviews and success stories that look too good to be true.

If you are one of those millions of people looking for a shortcut to weight loss, you probably have tried numerous weight loss pills, fat burners, and fat melters.
Sadly, the results are mostly disappointing, and you are left with nothing more than a feeling of being fooled by the marketing gimmicks that have little, if any, scientific backing.  

This article explores the science behind Lipozene. In addition, you will learn whether you should try it.

What is Lipozene? What Are Its Ingredients?

Lipozene is a brand of weight loss pill. It contains only one active ingredient, glucomannan. 

The inactive Lipozene ingredients include fillers, binders, color, gelatin, microcrystalline cellulose, magnesium silicate, stearic acid, and titanium dioxide. 

Each capsule contains 750 mg glucomannan. A single serving contains 2 capsules, which is equal to 1500 mg glucomannan. ORI recommends 2 capsules 30 minutes before meals up to three times per day with at least 8 oz. of water.

The source of glucomannan is the tuber or root of the elephant yam known as konjac (Amorphophallus konjac or Amorphophallus rivieri)
Glucomannan is a water-soluble fiber. The source of glucomannan is the tuber or root of the elephant yam known as konjac (Amorphophallus konjac or Amorphophallus rivieri).

Amylase enzyme produced by human salivary glands and pancreas cannot digest glucomannan. As a result, after ingestion, it reaches the large intestine without any significant change.

However, the friendly bacteria in the gut can digest (ferment) and use it as a source of nutrition for their growth.

Glucomannan is one of nature’s most viscous dietary fibers. 1 mg of glucomannan can absorb up to 50 mg of water. Theoretically, the high water absorption capacity increases the feelings of fullness, reduces appetite, and ultimately promotes weight loss.

Lipozene for Weight Loss: A Closer Look at the Scientific Evidence

Strong evidence has not yet supported the benefits of Lipozene in weight loss. 

That said, a few small studies have shown that Lipozene might aid weight loss. The problem with these studies is that they are small and have failed to show significant differences between the Lipozene and non-Lipozene groups. 

Here, we have compiled a list of most relevant studies on the effects of Lipozene on weight loss. 

  • In 1995, a team of investigators compared the effects of a low-calorie diet plus glucomannan with a low-calorie diet plus sugar pill. The study involved 30 individuals and lasted 2 months. 

At the end of the study, the investigators found that glucomannan plus low-calorie diet was more effective in reducing weight and increasing satiety. 

  • A 2005 study revealed that glucomannan plus a 1200-calorie diet caused greater weight loss than diet alone in healthy overweight individuals. 
  • In a 2013 study, researchers randomly divided 53 overweight and moderately obese adults into two groups. 

Participants in the first group were given 1.33 grams of glucomannan with 8oz. of water one hour before breakfast, lunch, and dinner. 

On the other hand, participants in the second group (the placebo group) were given dummy capsules. They took the capsules with the same amount of water one hour before breakfast, lunch, and dinner. 

After 8 weeks, the researchers observed that glucomannan supplementation did not produce significant differences in weight loss, hunger, and body composition between the two groups. 

  • A 2014 study analyzed and reviewed 9 trials. The investigators found that weight loss in the glucomannan group did not significantly differ from that in the placebo group.
  • According to a 2018 study, consuming konjac glucomannan in a noodle form could help promote weight loss by decreasing energy intake. Nonetheless, Lipozene is available as capsules. It means the results of this study do not directly point towards the benefits of Lipozene.

Moreover, the study involved only 16 young individuals with normal BMI. Therefore, it is not sure if the same effects would be seen in overweight or obese people of other ages. 

Does Lipozene Work? Is It Safe?

Many people willing to take Lipozene have one common question – “does it really work to aid weight loss”? The simple answer to this million-dollar question is “NO”. 

Looking at the current evidence, it’s safe to say that Lipozene is not an effective weight loss solution, at least not the way it is promoted to be. Simply put, it is neither a weight loss breakthrough nor an innovative weight loss pill. 


Dietary fibers have always been revered for their ability to promote and maintain weight loss. Glucomannan, the active ingredient in Lipozene, is just a kind of fiber. This means other dietary fibers can be as effective as Lipozene. 

Regarding the positive results in some studies, it is wise to say that Lipozene could work for a very small number of consumers. Even in such cases, no one exactly knows if the supplement works alone or in combination with a low-calorie diet and exercise. 

In fact, the European Food Safety Authority (EFSA) states,Glucomannan contributes to the reduction of body weight in the context of an energy-restricted diet”.

Some people also ask, “How fast does Lipozene work?” It may take months or even a year but the safety of long-term use of glucomannan supplements is not well documented. Health professionals do not recommend using Lipozene or any other similar supplements for longer durations due to potential safety concerns. 

When you use it as directed, Lipozene is safe. Make sure to take Lipozene capsule with sufficient water to avoid choking and blockages in the intestines. 

Glucomannan has an excellent safety profile and is unlikely to cause any serious problems. Besides, the US FDA has recognized the inactive Lipozene ingredients as safe. Safety should not be a concern unless you are sensitive to any of these ingredients. 

Lipozene Side Effects & Complaints

Typically, a person who has taken glucomannan supplement can have one or more of the following complaints:

  • Bloating
  • Gas
  • Diarrhea
  • Constipation
  • Upset stomach

Notably, these side effects are transient and mild. A sudden increase in fiber intake could be the reason behind them. Usually, these side effects clear on their own within a few weeks. 

People who have diabetes may experience a sudden drop in their blood glucose levels, which can be dangerous. Thus, if you take oral diabetes medication or insulin, it is important to take these medications 1 hour before or 4 hours after glucomannan administration. 

A few case reports have linked glucomannan consumption to cholestatic hepatitis and occupational asthma. However, these cases are very rare. 

It is not clear whether Lipozene is safe during pregnancy and lactation. For this reason, health professionals do not recommend it if you are pregnant or breastfeeding. 

Key Takeaways

As a super fiber or the weight-loss breakthrough, Lipozene is no shortcut to dramatic or long-lasting weight loss.
Most importantly, the seller of Lipozene, Obesity Research Institute LLC does not have a glorious history either. 

In 2005, the company paid $1.5 million to its customers after the Federal Trade Commission (FTC) found that ads for its glucomannan-containing supplements Propolene and FiberThin (both defunct now) contained misleading information, according to an article in Los Angeles Times. 

The claim – weight loss of more than 2 pounds per week without diet or exercise – does not look achievable. Remember Lipozene is another similar product from the same company!

At the time of writing this article, Lipozene’s website states that the supplement is “clinically proven to help you lose weight”. However, the company cites only one study and there is no link to the full paper. 

You cannot fully rely on the claims based on the findings of a single study. Moreover, because no one has access to the full paper, the claims appear even more unreliable. 

The bottom line is Lipozene may aid weight loss when you eat a low-calorie diet and do regular physical activity. Interestingly, increasing your daily fiber intake through diet could be equally effective. 

Remember Lipozene alone is not effective. It won’t give you a slimmer body or supercharge your metabolism. 

Go for Other Safer and Effective Options

If you are seriously looking to shed some pounds, you could consider many other effective methods. One of them is intermittent fasting. 

Numerous scientific studies have revealed that intermittent fasting, which involves cycles of fasting and feeding periods, is a highly effective way to promote “healthy” weight loss. 

There are different ways to do intermittent fasting. These include the 5:2 diet, 12-hours fasts, 16-hour fasts, 20-hours fasts, and 24-hour fasts. 

You will have to find the approach that meets your unique individual needs so that you can get the best results. 

For this, you will need a team of experts. The team will carefully study your unique physical parameters and design an intermittent fasting diet protocol to give you the best possible outcome.